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Treatment Pathway

Ketamine-assisted therapy.

A legal, fast-acting and medically supervised therapy producing meaningful relief for depression, PTSD, anxiety and suicidality — often within days, not months.

What is ketamine therapy?

Ketamine is an FDA-approved anesthetic that, at low sub-anesthetic doses, has been shown to rapidly reduce symptoms of treatment-resistant depression, PTSD, anxiety and acute suicidality. Unlike traditional antidepressants, which can take weeks to work, many patients experience relief within hours or days of their first session.

Ketamine acts on the brain's glutamate system and promotes neuroplasticity — the ability to form new neural connections. Combined with psychotherapy, this creates a unique window in which entrenched patterns of trauma, depression and addictive behavior can be re-examined and rewired.

What it can help with

Treatment-resistant depression

For those who have not responded to multiple SSRIs or traditional therapy.

PTSD & complex trauma

Including veterans, first responders, and survivors of abuse.

Suicidal ideation

Ketamine can rapidly reduce suicidal thoughts, often within hours.

Severe anxiety & OCD

When standard medications and CBT have plateaued.

Substance use disorders

Emerging evidence for alcohol and stimulant use disorders.

Chronic pain with depression

Dual benefit for patients living with both.

How treatment works

A standard course unfolds over 2–3 weeks, with each session followed by integration therapy to translate the experience into lasting change.

Phase 1

Medical & psychiatric intake

Full evaluation of medical history, medications, and mental health goals. Ketamine is screened against cardiovascular and psychiatric risk factors before any session is scheduled.

Phase 2

Ketamine sessions

A typical protocol is 6 sessions over 2–3 weeks, delivered as IV infusions, IM injections, or supervised sublingual lozenges. Each session lasts 45–90 minutes in a calm, monitored clinical setting.

Phase 3

Integration & maintenance

Therapy between and after sessions helps translate insights into lasting change. Many patients continue with periodic maintenance doses and ongoing counseling.

Legal & accessible in the US

Available today — in clinics across the country.

Ketamine is one of the only legal psychedelic-adjacent therapies currently available in the United States. It is administered off-label for mental health by licensed physicians, psychiatrists, and anesthesiologists in dedicated ketamine clinics.

The FDA-approved nasal spray Spravato (esketamine) is covered by many insurance plans for treatment-resistant depression. Off-label IV and IM ketamine is typically paid out of pocket, though some insurers are beginning to reimburse it. Hashiveinu helps families navigate cost, coverage and clinic selection.

How we help

We help you find the right ketamine program — safely.

Not every ketamine clinic is the same. Quality, safety protocols and integration support vary enormously. Hashiveinu works with a vetted network of physician-led clinics that pair ketamine with proper psychotherapy — not just an infusion in a chair.

We help you:

  • Determine whether ketamine is medically appropriate
  • Find a reputable, physician-led clinic with integration therapy
  • Navigate insurance, Spravato coverage, and out-of-pocket options
  • Coordinate aftercare and ongoing counseling
  • Access financial assistance when cost is a barrier

A note on safety: Ketamine should only be taken under medical supervision in a licensed clinic. Unsupervised recreational use carries risks of bladder damage, dissociation and dependence. We only refer to clinics with proper medical screening, monitoring and integration support.

Frequently asked questions

Honest answers to the questions families ask us most often.

Yes. Ketamine is FDA-approved as an anesthetic and is legally prescribed off-label for depression, PTSD, anxiety and suicidality by licensed physicians and psychiatrists. The FDA has also specifically approved Spravato (esketamine) nasal spray for treatment-resistant depression.

When administered in a licensed clinic with medical screening and monitoring, ketamine has a strong safety profile. We only refer to physician-led clinics with proper cardiovascular and psychiatric evaluation, monitoring during sessions, and integration support. Unsupervised recreational use carries real risks and should be avoided.

Ketamine is most established for treatment-resistant depression, PTSD, severe anxiety, OCD and acute suicidality. There is also growing evidence for alcohol and stimulant use disorders, and for chronic pain with co-occurring depression.

Many patients experience meaningful relief within hours or days of their first session — far faster than traditional antidepressants, which can take weeks. A full response typically builds over a course of 6 sessions across 2–3 weeks.

A standard protocol is 6 sessions over 2–3 weeks, delivered as IV infusions, IM injections, or supervised sublingual lozenges. Each session lasts 45–90 minutes in a calm, monitored clinical setting, with integration therapy between and after sessions.

Spravato (esketamine) nasal spray is covered by many insurance plans for treatment-resistant depression. Off-label IV and IM ketamine is typically paid out of pocket, though some insurers are beginning to reimburse it. We help families navigate coverage and find financial assistance when cost is a barrier.

Out-of-pocket costs typically range from $400–$800 per session, with a full initial course running $2,400–$5,000. Spravato through insurance can be significantly less. Hashiveinu helps identify affordable, reputable clinics and financial assistance options.

Reach out through our Get Help page. We'll set up a confidential conversation to understand the situation, determine whether ketamine is medically appropriate, and connect you with a vetted clinic and integration support.

Bring them back — start the conversation.

Speak with our team confidentially to learn whether ketamine therapy may be right for your loved one.

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